Laser Assisted Drug Delivery

Laser Assisted Drug Delivery

Administering medication and getting the most out of medical drugs is a priority for surgeons looking to help their patients get the best results from any surgical or non-surgical procedure. Laser-assisted drug delivery (LADD), a revolutionary new technique, is rapidly growing in popularity as a way of administering medications through the skin.

Here, Dr. Jose Barrera of San Antonio, Texas, discusses laser-assisted drug delivery in San Antonio, examining the technology in detail so you and other patients can understand its potential benefits. You can learn more about the procedure by scheduling a consultation with Dr. Barrera. 

What is Laser-Assisted Drug Delivery (LADD)?

A rapidly growing technique, LADD is a non-invasive technique that uses laser energy to enhance a patient’s skin’s permeability. This facilitates the faster, more efficient delivery of medications, improving price margins and also results. The process involves the following steps:

A carefully calibrated laser is applied to the skin, creating microscopic channels or pores. This process, known as laser ablation, modifies the skin’s outermost layer. This outer layer is the primary barrier to topical applications, and by temporarily modifying it, making it more “permeable,” LADD helps increase the uptake and effectiveness of topical medications and agents.

Following the laser treatment, a topical medication is applied to the skin. These drug molecules can now penetrate the skin more easily through the microscopic channels created by the laser.

Once the medication has been applied, it is absorbed into the targeted tissues or bloodstream, where it can exert its intended effects on the patient’s skin or body.

Currently, LADD is non-FDA approved; however, as the procedure continues to grow in popularity, it is likely it will receive an FDA stamp within the next few years.

Advancements in Laser Technology

Thanks to the ongoing development of new laser technologies, LADD has seen significant improvements over the past several years.  

These innovations have made the process more precise, efficient, and safe, helping patients receive better treatment outcomes and reduced side effects. Some of the most notable advancements in laser technology and their impact on drug delivery include:

Fractional lasers

Fractional lasers have revolutionized the field of LADD by providing a more controlled and targeted approach to creating microscopic channels in the skin. Unlike traditional ablative lasers, which remove the entire surface layer of the skin, fractional lasers emit microbeams of light that create a pattern of microscopic treatment zones, leaving the surrounding tissue intact. This approach minimizes damage to healthy skin and promotes faster healing.

Some key features of fractional lasers include:

  • Adjustable parameters: Fractional lasers offer greater control over treatment depth, density, and energy levels, allowing physicians to customize the procedure for each patient’s needs.
  • Reduced downtime: Fractional lasers’ ability to spare the surrounding tissue results in faster recovery times and less post-treatment redness and swelling.
  • Improved safety: The selective nature of fractional lasers reduces the risk of complications, such as scarring and infection.

Picosecond lasers

Picosecond lasers are another advancement in laser technology that improves the efficacy of LADD.  These rapid-pulse lasers allow for more efficient and precise ablation of the skin, with minimal heat transfer to surrounding tissues. As a result, picosecond lasers can be used for a wide range of applications, including drug delivery and aesthetic treatments.


Benefits of picosecond lasers in drug delivery include:

  • Precision: The ultra-short pulse duration allows for highly precise and controlled ablation of the skin, reducing the risk of damage to adjacent tissues.
  • Efficiency: Picosecond lasers can create a higher density of microscopic channels in the skin, enhancing drug penetration and delivery.
  • Versatility: Picosecond lasers can be used for a variety of drug delivery applications, including the treatment of dermatological conditions, pain relief, and skin rejuvenation.

Nanotechnology in laser-assisted drug delivery

Another avenue in the development of LADD technology is the integration of nanotechnology. Researchers are exploring the use of nanoparticles to improve the delivery and efficacy of various drugs. For example, drug-loaded nanoparticles can be incorporated into topical formulations, allowing for more efficient penetration through the microscopic channels created by lasers.

Nanotechnology offers several advantages in drug delivery:

  • Controlled Release: Nanoparticles can be designed to release their drug payload in a controlled manner, ensuring optimal drug concentrations at the target site.
  • Enhanced Stability: The encapsulation of drugs within nanoparticles can protect them from degradation, prolonging their therapeutic effect.
  • Targeted Delivery: Functionalized nanoparticles can be engineered to recognize and bind to specific cell types, allowing for targeted drug delivery and reduced side effects.

Applications of Laser-Assisted Drug Delivery in Plastic Surgery

LADD has a wide range of clinical applications, including:

Conditions such as psoriasis, atopic dermatitis, and vitiligo can benefit from the targeted delivery of medications like corticosteroids and calcineurin inhibitors.

Topical analgesics and anti-inflammatory drugs can be delivered more efficiently to provide relief for conditions like osteoarthritis and neuropathic pain.

Laser-assisted delivery of anti-aging compounds, like growth factors and antioxidants, can enhance the efficacy of skin rejuvenation treatments.

Enhanced delivery of chemotherapeutic agents, like 5-fluorouracil, can improve treatment outcomes for non-melanoma skin cancers.

Benefits of Laser-Assisted Drug Delivery

There are several advantages to using LADD over traditional methods of drug administration. These include:

Enhanced skin permeability allows for higher drug concentrations in the targeted tissues, improving treatment outcomes.

By delivering drugs directly to the affected area, systemic exposure and side effects can be minimized.

The non-invasive nature of the procedure reduces discomfort and improves patient adherence to treatment regimens.

The Future of Laser-Assisted Drug Delivery

As research continues, professionals expect LADD to play a far more prominent role in the management of various medical conditions.

Researchers are exploring the use of nanotechnology to further improve drug delivery, as well as investigating the potential for combining laser treatments with other energy-based devices for enhanced treatment outcomes. It is also likely that the procedure will become more widespread, along with an FDA approval.

Laser-Assisted Drug Delivery in San Antonio, TX

LADD allows patients and surgeons to get the most out of medications involved in a wide range of surgical and non-surgical procedures. To learn more about how Dr. Barrera can use LADD to help you improve results, contact Dr Jose Barrera via his online form or by calling (210) 468 5426.